Asymmetric binding of transferrin receptor to parvovirus capsids.

  title={Asymmetric binding of transferrin receptor to parvovirus capsids.},
  author={Susan Hafenstein and Laura M. Palermo and Victor A. Kostyuchenko and Chuan Xiao and Marc C. Morais and Christian D. S. Nelson and Valorie D. Bowman and Anthony J. Battisti and Paul R. Chipman and Colin R Parrish and Michael G. Rossmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 16},
Although many viruses are icosahedral when they initially bind to one or more receptor molecules on the cell surface, such an interaction is asymmetric, probably causing a breakdown in the symmetry and conformation of the original infecting virion in preparation for membrane penetration and release of the viral genome. Cryoelectron microscopy and biochemical analyses show that transferrin receptor, the cellular receptor for canine parvovirus, can bind to only one or a few of the 60… CONTINUE READING