Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl phosphatidic acid bilayers.

@article{Galla1980AsymmetricAE,
  title={Asymmetric antagonistic effects of an inhalation anesthetic and high pressure on the phase transition temperature of dipalmitoyl phosphatidic acid bilayers.},
  author={H. Galla and J. Trudell},
  journal={Biochimica et biophysica acta},
  year={1980},
  volume={599 1},
  pages={
          336-40
        }
}
  • H. Galla, J. Trudell
  • Published 1980
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The phase transition temperature (Tt) of dipalmitoyl phosphatidic acid multilamellar liposomes is depressed 10 degrees C by the inhalation anesthetic methoxyflurane at a concentration of 100 mmol/mol lipid. Application of 100 atm of helium pressure to pure phosphatidic acid liposomes increased Tt only 1.5 degrees C. However, application of 100 atm helium pressure to dipalmitoyl phosphatidic acid lipsomes containing 100 mmol methoxyflurane/mol lipid almost completely antagonized the effect of… CONTINUE READING
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