Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements.

@article{Norris1999AsymmetricAN,
  title={Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements.},
  author={Dominic P. Norris and Elizabeth J Robertson},
  journal={Genes & development},
  year={1999},
  volume={13 12},
  pages={1575-88}
}
The TGFbeta-related molecule Nodal is required for establishment of the anterior-posterior (A-P) and left-right (L-R) body axes of the vertebrate embryo. In mouse, several discrete sites of nodal activity closely correlate with its highly dynamic expression domains. nodal function in the posterior epiblast promotes primitive streak formation, whereas transient nodal expression in the extraembryonic visceral endoderm is essential for patterning the rostral central nervous system. Asymmetric… CONTINUE READING