Asymmetric Synthesis of the Antiviral Diterpene Wickerol A.

Abstract

Wickerol A (1) is an unusual diterpene with remarkable activity against the H1N1 influenza virus. Its tetracyclic skeleton contains three quaternary carbons and is marked by several syn-pentane interactions which force a six-membered ring into a twist-boat conformation. We present an asymmetric synthesis of wickerol A (1) that is based on a Jung Diels-Alder… (More)
DOI: 10.1021/jacs.7b05046

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