Asymmetric Phase‐Transfer Catalysis by Quaternary Ammonium Ions Derived from Cinchona‐Alkaloid Analogs Containing 1,1′‐Binaphthalene Moieties

@inproceedings{Ducry1999AsymmetricPC,
  title={Asymmetric Phase‐Transfer Catalysis by Quaternary Ammonium Ions Derived from Cinchona‐Alkaloid Analogs Containing 1,1′‐Binaphthalene Moieties},
  author={Laurent Ducry and François Diederich},
  year={1999}
}
The synthesis and catalytic properties of a new type of enantioselective phase-transfer catalysts, incorporating both the quinuclidinemethanol fragment of Cinchona alkaloids and a 1,1′-binaphthalene moiety, are described. Catalyst (+)-(aS,3R,4S,8R,9S)-4 with the quinuclidine fragment attached to C(7′) in the major groove of the 1,1′-binaphthalene residue was predicted by computer modeling to be an efficient enantioselective catalyst for the unsymmetric alkylation of 6,7-dichloro-5-methoxy-2… CONTINUE READING