Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation.

@article{Lin2015AsymmetricPS,
  title={Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation.},
  author={Wen-Hsuan W Lin and W Christopher Adams and Simone A Nish and Yen-Hua Chen and Bonnie Yen and Nyanza J Rothman and Radomir Kratchmarov and Takaharu Okada and Ulf Klein and Steven L Reiner},
  journal={Cell reports},
  year={2015},
  volume={13 10},
  pages={2203-18}
}
Metazoan sibling cells often diverge in activity and identity, suggesting links between growth signals and cell fate. We show that unequal transduction of nutrient-sensitive PI3K/AKT/mTOR signaling during cell division bifurcates transcriptional networks and fates of kindred cells. A sibling B lymphocyte with stronger signaling, indexed by FoxO1 inactivation and IRF4 induction, undergoes PI3K-driven Pax5 repression and plasma cell determination, while its sibling with weaker PI3K activity… CONTINUE READING
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