Asymmetric DNA requirements in Xer recombination activation by FtsK

  title={Asymmetric DNA requirements in Xer recombination activation by FtsK},
  author={Laetitia Bonn{\'e} and Sarah Bigot and Fabien Chevalier and J F Allemand and François-Xavier Barre},
  booktitle={Nucleic acids research},
In bacteria with circular chromosomes, homologous recombination events can lead to the formation of chromosome dimers. In Escherichia coli, chromosome dimers are resolved by the addition of a crossover by two tyrosine recombinases, XerC and XerD, at a specific site on the chromosome, dif. Recombination depends on a direct contact between XerD and a cell division protein, FtsK, which functions as a hexameric double stranded DNA translocase. Here, we have investigated how the structure and… CONTINUE READING
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