Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide iota.

Abstract

The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemic Josiphos-related ligand (R,S)-PPF-P(t-Bu)2 was successfully used to introduce each of three stereocenters found in the target compound. 

Cite this paper

@article{Lipshutz2007AsymmetricCH, title={Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide iota.}, author={Bruce H Lipshutz and Ching-Tien Lee and Jeff M Servesko}, journal={Organic letters}, year={2007}, volume={9 23}, pages={4713-6} }