Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky

@article{Stavenger2001AsymmetricCI,
  title={Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this research, and Dr. John Tallarico and Max Narovlyansky },
  author={R. A. Stavenger and S. Schreiber},
  journal={Angewandte Chemie},
  year={2001},
  volume={40 18},
  pages={
          3417-3421
        }
}
Small molecules have been used to explore many facets of biology for over a century. However, research in biology is not routinely performed using this approach, in the way that it is with biochemical, genetic, and increasingly, genomic approaches. Several problems limit the use of the former approach. Arguably, the primary one is the lack of routine access to structurally complex and diverse small molecules that can be used to modulate biological systems.[1] Diversityoriented organic synthesis… Expand
53 Citations
Carbohydrates in diversity-oriented synthesis: challenges and opportunities.
  • 27
A one-bead, one-stock solution approach to chemical genetics: part 1.
  • 81
Diversity-oriented synthesis; a challenge for synthetic chemists.
  • D. R. Spring
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • 2003
  • 251
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Target-oriented and diversity-oriented organic synthesis in drug discovery.
  • 1,724
  • PDF
...
1
2
3
...