Asymmetric Aldol/Vinylogous Aldol/Cyclization Reaction Using Phosphine Oxide Catalysts.

Abstract

Chiral phosphine oxide sequentially activates silicon tetrachloride and trichlorosilyl enol ethers to facilitate asymmetric aldol/vinylogous aldol reaction of 4-methoxy-3-penten-2-one and conjugated aldehydes in a highly enantioselective fashion, and the subsequent cyclization produced optically active 2,6-disubstituted 2,3-dihydro-4-pyranones bearing… (More)
DOI: 10.1248/cpb.c17-00540

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Cite this paper

@article{Alim2017AsymmetricAA, title={Asymmetric Aldol/Vinylogous Aldol/Cyclization Reaction Using Phosphine Oxide Catalysts.}, author={Nathan Ray Alim and Shiki Miyazaki and Yasushi Shimoda and Masaharu Sugiura and Makoto Nakajima and Shunsuke Kotani}, journal={Chemical & pharmaceutical bulletin}, year={2017}, volume={65 10}, pages={989-993} }