Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.

@article{Tess2017Asy2Mer2AE,
  title={Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.},
  author={Sophie Tess{\'e} and Henri-Marc Bourbon and Robert Debuchy and Karine Budin and Emeline Dubois and Zhang Liangran and Romain Antoine and Tristan Piolot and Nancy E Kleckner and Dietrich Zickler and Eric Espagne},
  journal={Genes & development},
  year={2017},
  volume={31 18},
  pages={
          1880-1893
        }
}
Meiosis is the cellular program by which a diploid cell gives rise to haploid gametes for sexual reproduction. Meiotic progression depends on tight physical and functional coupling of recombination steps at the DNA level with specific organizational features of meiotic-prophase chromosomes. The present study reveals that every step of this coupling is mediated by a single molecule: Asy2/Mer2. We show that Mer2, identified so far only in budding and fission yeasts, is in fact evolutionarily… CONTINUE READING
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