Astronomical algorithms for automated analysis of tissue protein expression in breast cancer

@inproceedings{Ali2013AstronomicalAF,
  title={Astronomical algorithms for automated analysis of tissue protein expression in breast cancer},
  author={Hamid Raza Ali and Melinda Irwin and Lorna Morris and Steven J. Dawson and Fiona M. Blows and Elena Provenzano and Betania Mahler-Araujo and Paul P. D. Pharoah and Nicholas Walton and James D. Brenton and Carlos Caldas},
  booktitle={British Journal of Cancer},
  year={2013}
}
Background:High-throughput evaluation of tissue biomarkers in oncology has been greatly accelerated by the widespread use of tissue microarrays (TMAs) and immunohistochemistry. Although TMAs have the potential to facilitate protein expression profiling on a scale to rival experiments of tumour transcriptomes, the bottleneck and imprecision of manually scoring TMAs has impeded progress.Methods:We report image analysis algorithms adapted from astronomy for the precise automated analysis of IHC in… CONTINUE READING
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