Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.

@article{Fedele2005AstrogliosisIE,
  title={Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.},
  author={Denise E Fedele and Nicolette Gouder and Martin G{\"u}ttinger and Laetitia Gabernet and Louis Scheurer and Thomas R{\"u}licke and Florence Crestani and Detlev Boison},
  journal={Brain : a journal of neurology},
  year={2005},
  volume={128 Pt 10},
  pages={2383-95}
}
Adenosine kinase (ADK) is considered to be the key regulator of the brain's endogenous anticonvulsant, adenosine. In adult brain, ADK is primarily expressed in a subpopulation of astrocytes and striking upregulation of ADK in these cells has been associated with astrogliosis after kainic acid-induced status epilepticus (KASE) in the kainic acid mouse model of temporal lobe epilepsy. To investigate the causal relationship between KASE-induced astrogliosis, upregulation of ADK and seizure… CONTINUE READING