Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease.

@article{Dervan2004AstroglialPA,
  title={Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease.},
  author={Adrian G Dervan and Charles K. Meshul and Mitchell Beales and Gethin J. McBean and Cindy Moore and Susan Totterdell and Ann K. Snyder and Gloria E. Meredith},
  journal={Experimental neurology},
  year={2004},
  volume={190 1},
  pages={145-56}
}
Astrocytes play a major role in maintaining low levels of synaptically released glutamate, and in many neurodegenerative diseases, astrocytes become reactive and lose their ability to regulate glutamate levels, through a malfunction of the glial glutamate transporter-1. However, in Parkinson's disease, there are few data on these glial cells or their regulation of glutamate transport although glutamate cytotoxicity has been blamed for the morphological and functional decline of striatal neurons… CONTINUE READING
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