Astroglial glutamate transporters coordinate excitatory signaling and brain energetics.

@article{Robinson2016AstroglialGT,
  title={Astroglial glutamate transporters coordinate excitatory signaling and brain energetics.},
  author={Michael B Robinson and Joshua G Jackson},
  journal={Neurochemistry international},
  year={2016},
  volume={98},
  pages={56-71}
}
In the mammalian brain, a family of sodium-dependent transporters maintains low extracellular glutamate and shapes excitatory signaling. The bulk of this activity is mediated by the astroglial glutamate transporters GLT-1 and GLAST (also called EAAT2 and EAAT1). In this review, we will discuss evidence that these transporters co-localize with, form physical (co-immunoprecipitable) interactions with, and functionally couple to various 'energy-generating' systems, including the Na(+)/K(+)-ATPase… CONTINUE READING
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