Astroglia-released factor with negative allosteric modulatory properties at the GABA A receptor.

@article{Rigo1996AstrogliareleasedFW,
  title={Astroglia-released factor with negative allosteric modulatory properties at the GABA A receptor.},
  author={J M Rigo and Shibeshih Belachew and Paul Coucke and Pierre Leprince and Brigitte Malgrange and Bernard Rogister and Gustave Moonen},
  journal={Biochemical pharmacology},
  year={1996},
  volume={52 3},
  pages={465-73}
}
We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta-carboline-like properties, thus, likely to act at the benzodiazepine site. Here, using patch-clamp and binding techniques, we confirm that the low-molecular… CONTINUE READING