Astroglia contain a specific transport mechanism for N-acetyl-L-aspartate.

  title={Astroglia contain a specific transport mechanism for N-acetyl-L-aspartate.},
  author={Thomas Sager and Christian Fr\okjaer Thomsen and Jacob S. Valsborg and Henning Laursen and Anker Jon Hansen},
  journal={Journal of neurochemistry},
  volume={73 2},
N-Acetylaspartate (NAA) is the second most abundant amino acid in the adult brain. It is located and synthesized in neurons and probably degraded in the glia compartment, but the transport mechanisms are unknown. Rat primary neuron and astrocyte cell cultures were exposed to the L isomer of [3H]NAA and demonstrated concentration-dependent uptake of [3H]NAA with a Km approximately 80 microM. However, Vmax was 23+/-6.4 pmol/mg of protein/min in astrocytes but only 1.13+/-0.4 pmol/mg of protein… CONTINUE READING
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