Astrocytopathy in Baló’s disease

@article{Kira2011AstrocytopathyIB,
  title={Astrocytopathy in Bal{\'o}’s disease},
  author={Jun-ichi Kira},
  journal={Multiple Sclerosis Journal},
  year={2011},
  volume={17},
  pages={771 - 779}
}
  • J. Kira
  • Published 1 April 2011
  • Medicine
  • Multiple Sclerosis Journal
Baló’s disease is characterized by alternating rings of demyelination and preserved myelin. As additional multiple sclerosis (MS)-like lesions often coexist in Baló’s cases, Baló’s disease is regarded as a variant of MS. In demyelinated areas, many hypertrophic astrocytes are present in close contact with oligodendrocytes, which often show apoptotic features. In the outermost layer of preserved myelin, stress proteins involved in tissue preconditioning are abundant in oligodendrocytes. The peri… 
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An autopsy case of middle-aged female with a chronic history of MS newly relapsed with atypical demyelinating lesions, which showed concurrent features of BCS and SD is described and the overlapping features between these two variants are discussed.
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It is the opinion is that treatment with multiple sclerosis disease-modifying therapy would seem reasonable for patients with Baló lesions who also fulfil standard diagnostic criteria for multiple sclerosis.
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Autoimmunity in neuromyelitis optica and opticospinal multiple sclerosis: Astrocytopathy as a common denominator in demyelinating disorders
  • J. Kira
  • Medicine
    Journal of the Neurological Sciences
  • 2011
TLDR
It is proposed that anti-AQP4 antibody-dependent AQP4 loss occurs in some NMO patients while antibody-independent AQP 4 astrocytopathy can occur in heterogeneous demyelinating conditions, including Baló's disease, NMO and MS.
Multiple Sclerosis: Destruction and Regeneration of Astrocytes in Acute Lesions
TLDR
Loss and recovery of astrocytes in new MS lesions may be as important as myelin loss as a cause of conduction block responsible for symptoms in patients with relapsing and remitting and secondary progressive MS.
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