Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.

@article{Cekanaviciute2014AstrocyticTG,
  title={Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.},
  author={Egle Cekanaviciute and Nancy Fathali and Kristian P Doyle and Aaron M. Williams and Jullet Han and Marion S Buckwalter},
  journal={Glia},
  year={2014},
  volume={62 8},
  pages={
          1227-40
        }
}
Astrocytes limit inflammation after CNS injury, at least partially by physically containing it within an astrocytic scar at the injury border. We report here that astrocytic transforming growth factor-beta (TGFβ) signaling is a second, distinct mechanism that astrocytes utilize to limit neuroinflammation. TGFβs are anti-inflammatory and neuroprotective cytokines that are upregulated subacutely after stroke, during a clinically accessible time window. We have previously demonstrated that TGFβs… CONTINUE READING
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