Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy

@article{Komori1998AstrocyticPA,
  title={Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy},
  author={Takashi Komori and N Arai and Masaya Oda and Hiroshi Nakayama and Hideo Mori and Saburo Yagishita and Tetsuya Takahashi and Naoji Amano and Shigeo Murayama and Shinya Murakami and Noriyuki Shibata and M. Kobayashi and Shoichi Sasaki and Makoto Iwata},
  journal={Acta Neuropathologica},
  year={1998},
  volume={96},
  pages={401-408}
}
Abstract Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are characterized by their unique clinical features and neuronal pathology. Although astrocytic plaques and tufts of abnormal fibers have been suggested to be specific histopathologic markers, recent studies have revealed significant clinicopathologic overlap between CBD and PSP. Based on the distinctive camera lucida profile of astrocytic inclusions on Gallyas-Braak silver staining, we found that astrocytic… Expand
Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration
  • Mari Yoshida
  • Biology, Medicine
  • Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2014
TLDR
The characteristics of tau accumulation in both neurons and glia suggest a different underlying mechanism with regard to the sites of t Tau aggregation and fibril formation between PSP and CBD: proximal‐dominant aggregation of TAs and formation of filamentous NFTs in PSP in contrast to the distal‐dominate aggregation of APs and formationof less filamentous pretangles in CBD. Expand
Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD
TLDR
Results suggest that CBD-OPCA is a distinct clinicopathologic variant of CBD with olivopontocerebellar TDP-43 pathology, which met neuropathologic research diagnostic criteria for CBD and shared tau biochemical characteristics with typical CBD. Expand
Astrocytic tau pathology positively correlates with neurofibrillary tangle density in progressive supranuclear palsy
TLDR
The results suggest that TAs are part of the same pathologic process as NFTs in PSP, and that both might have a common accumulation of tau pathology. Expand
Chameleons and mimics: Progressive supranuclear palsy and corticobasal degeneration
  • M. Mimuro, Mari Yoshida
  • Medicine
  • Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2019
TLDR
PSP and CBD present clinically differential diagnostic difficulties because of their overlapping pathological distributions and clinical symptoms depend on the topographical distribution and severity of degeneration rather than on the type of aggregated protein or inclusions. Expand
Tau‐positive dial Inclusions in Progressive Supranuclear Palsy, Corticobasal Degeneration and Pick's Disease
  • T. Komori
  • Biology, Medicine
  • Brain pathology
  • 1999
TLDR
These distinctive glial lesions most likely reflect fundamental alterations in isoform composition of tau as well as its specific cellular and regional expression in sporadic tauopathies. Expand
Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration
TLDR
The present findings suggest that PSP and CBD are distinct pathological entities, however, there exist ‘atypical’ cases of PSP, and pathological heterogeneity in the clinical and pathological diagnosis of both disorders. Expand
Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration?
TLDR
The possibility that these two cases represent a new neuropathological phenotype of non-familial FTD rather than simply a variant of CBD cannot be completely excluded. Expand
4-repeat tauopathy sharing pathological and biochemical features of corticobasal degeneration and progressive supranuclear palsy
TLDR
It is reported that a 67-year-old man with 4-repeat (4R) tauopathy sharing both features of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) and immunoblotting of insoluble tau demonstrated the low molecular fragments observed in typical CBD and PSP, respectively, in addition to the presence of 4R tau isoforms. Expand
Office of Rare Diseases Neuropathologic Criteria for Corticobasal Degeneration
TLDR
Using neuropathologic criteria for corticobasal degeneration provides good differentiation of CBD from other tauopathies, except frontotemporal dementia and Parkinsonism linked to chromosome 17, where additional clinical or molecular genetic information is required to make an accurate diagnosis. Expand
Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain
TLDR
Intacerebral distribution of astrocytic plaques and tuft-shapedAstrocytes in autopsied brains of patients with either CBD or PSP differed greatly, and CBD and PSP can be considered different entities. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Plaque‐like structures in the cerebral cortex of corticobasal degeneration: A histopathologic marker?
TLDR
It is demonstrated by immunohistochemical study and Western blotting that immunoreactivity to the exon-3 tau molecule was either low or absent entirely in CBD brains, but abundant in PSP brains, and in order to compare PLS with TAF, archival autopsy material is examined. Expand
Immunohistochemical investigation of tau-positive structures in the cerebral cortex of patients with progressive supranuclear palsy
TLDR
It is demonstrated that coil-like structures (coiled bodies) are located in the oligodendroglial cell bodies of patients with progressive supranuclear palsy, and appear to be identical to 'astrocytic plaques' previously reported in patients with corticobasal degeneration (CBD). Expand
Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles. Very similar antigenicity of subcortical neuronal pathology in progressive supranuclear palsy and Alzheimer's disease.
TLDR
Light microscopic immunohistochemical investigations were performed on neurofibrillary tangles in four histologically confirmed cases of Alzheimer's disease and in five patients with a progressive supranuclear palsy, indicating a much more extensive disruption of fibrillar proteins in PSP subcortical neurons than previously reported. Expand
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Neuropathologic Overlap of Progressive Supranuclear Palsy, Pick's Disease and Corticobasal Degeneration
TLDR
Despite significant overlap among the three neurodegenerative diseases examined, the morphological and regional differences suggest that each is a distinct pathophysiological entity. Expand
Widespread cytoskeletal pathology characterizes corticobasal degeneration.
TLDR
It is demonstrated that the nonamyloid cortical plaques of CBD are actually collections of abnormal tau in the distal processes of astrocytes, which refines the diagnosis and pathophysiological understanding of this unique disease and has important implications for other neurodegenerative diseases, like Alzheimer's disease. Expand
Corticobasal degeneration.
TLDR
Despite some pathological similarities to Pick's disease, it is suggested that the distribution of nerve cell loss and the corticobasal inclusion are unique to corticOBasal degeneration. Expand
Morphologic difference of neuropil threads in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy: a morphometric study
TLDR
The study revealed that NTs in Alzheimer's disease, corticobasal degeneration and PSP were distinctively different with respect to their morphology. Expand
Appearance of paired nucleated, Tau-positive glia in patients with progressive supranuclear palsy brain tissue
TLDR
Many Tau-positive glia with paired nuclei and astrocyte type morphology were identified in three brains from patients with progressive supranuclear palsy, suggesting that there is an unusual gliotic reaction in PSP in brain areas which show relatively little neuronal loss. Expand
A variety of glial pathological structures by the modified Gallyas‐Braak method
TLDR
It is concluded that the tuft‐shaped astrocytes are favored in cases of progressive supranuclear palsy (PSP), and that there is a massive appearance of both the argyrophilic threads and the firework‐like structures characteristic in prototype of corticobasal degeneration (CBD). Expand
...
1
2
3
4
...