Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter.

@article{Wender2000AstrocyticGI,
  title={Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter.},
  author={Regina Wender and Antony M. Brown and Ricardo Fern and Raymond A Swanson and Kevin M. Farrell and Bruce R Ransom},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 18},
  pages={
          6804-10
        }
}
We tested the hypothesis that astrocytic glycogen sustains axon function during and enhances axon survival after 60 min of glucose deprivation. Axon function in the rat optic nerve (RON), a CNS white matter tract, was monitored by measuring the area of the stimulus-evoked compound action potential (CAP). Switching to glucose-free artificial CSF (aCSF) had no effect on the CAP area for approximately 30 min, after which the CAP rapidly failed. Exposure to glucose-free aCSF for 60 min caused… CONTINUE READING

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