Astrocytic gap junctions remain open during ischemic conditions.

  title={Astrocytic gap junctions remain open during ischemic conditions.},
  author={Maria Luisa Cotrina and Jiansheng Kang and Jane H-C Lin and Emilio Bueno and Thomas W Hansen and Liming He and Yingru Liu and Maiken Nedergaard},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 7},
Gap junctions are highly conductive channels that allow the direct transfer of intracellular messengers such as Ca2+ and inositol triphosphate (IP3) between interconnected cells. In brain, astrocytes are coupled extensively by gap junctions. We found here that gap junctions among astrocytes in acutely prepared brain slices as well as in culture remained open during ischemic conditions. Uncoupling first occurred after the terminal loss of plasma membrane integrity. Gap junctions therefore may… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS