Astrocytic alteration induced by Japanese encephalitis virus infection.

  title={Astrocytic alteration induced by Japanese encephalitis virus infection.},
  author={Chun-Jung Chen and S L Liao and M D Kuo and Yuan Wang},
  volume={11 9},
The neurotropism of Japanese encephalitis virus (EV) has not been well characterized. Astrocytes are parts of the blood-brain barrier, a major source of chemokines, and critical effectors of central inflammation. Thus, astrocytes might play some role as JEV travels from the peripheral to the CNS and/or the resultant encephalitis. Using rat cortical cultures, we found that JEV can cause cellular and/or functional changes in astrocytes as indicated by increased expression of interleukin-6 (IL-6… CONTINUE READING