Astrocytic Purinergic Signaling Coordinates Synaptic Networks

  title={Astrocytic Purinergic Signaling Coordinates Synaptic Networks},
  author={O. Pascual and K. B. Casper and C. Kubera and J. Zhang and R. Revilla-Sanchez and J. Sul and H. Takano and S. Moss and K. McCarthy and P. Haydon},
  pages={113 - 116}
  • O. Pascual, K. B. Casper, +7 authors P. Haydon
  • Published 2005
  • Biology, Medicine
  • Science
  • To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes to block the release of transmitters from these glial cells. By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing the dynamic range for long-term potentiation and mediated activity-dependent, heterosynaptic depression. These… CONTINUE READING
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