• DOI:10.1126/SCIENCE.1116916
Corpus ID: 36808788

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

@article{Pascual2005AstrocyticPS,
  title={Astrocytic Purinergic Signaling Coordinates Synaptic Networks},
  author={O. Pascual and K. B. Casper and C. Kubera and J. Zhang and R. Revilla-Sanchez and J. Sul and H. Takano and S. Moss and K. McCarthy and P. Haydon},
  journal={Science},
  year={2005},
  volume={310},
  pages={113 - 116}
}

O. Pascual, K. B. Casper, +7 authors P. Haydon

Published 2005

Biology, Medicine

Science

To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes to block the release of transmitters from these glial cells. By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing the dynamic range for long-term potentiation and mediated activity-dependent, heterosynaptic depression. These… CONTINUE READING

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