Astrocytic Purinergic Signaling Coordinates Synaptic Networks

@article{Pascual2005AstrocyticPS,
  title={Astrocytic Purinergic Signaling Coordinates Synaptic Networks},
  author={Olivier Pascual and Kristen B. Casper and Cathryn L. Kubera and Jing Zhang and Raquel Revilla-Sanchez and Jai-Yoon Sul and Hajime Takano and Stephen J. Moss and Ken D. McCarthy and Philip G Haydon},
  journal={Science},
  year={2005},
  volume={310},
  pages={113 - 116}
}
To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes to block the release of transmitters from these glial cells. By releasing adenosine triphosphate, which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission, thereby enhancing the dynamic range for long-term potentiation and mediated activity-dependent, heterosynaptic depression. These… 
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