Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice

@inproceedings{Wang2018AstrocyticJD,
  title={Astrocytic JWA deletion exacerbates dopaminergic neurodegeneration by decreasing glutamate transporters in mice},
  author={Rihua Wang and Xue Zhu Zhao and Jin Xu and Yifan Wen and Aiping Li and Ming Lu and Jianwei Zhou},
  booktitle={Cell Death & Disease},
  year={2018}
}
Astrocytic JWA exerts neuroprotective roles by alleviating oxidative stress and inhibiting inflammation. However, the molecular mechanisms of how astrocytic JWA is involved in dopaminergic neurodegeneration in Parkinson’s disease (PD) remain largely unknown. In this study, we found that astrocyte-specific JWA knockout mice (JWA CKO) exacerbated dopamine (DA… CONTINUE READING