Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome.

@article{Hodges2017AstrocyticCT,
  title={Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome.},
  author={Jennifer L. Hodges and Xinzhu Yu and Anthony Gilmore and Hannah Bennett and Michelle Tjia and James F Perna and Chia-Chien Chen and Xiang Li and Ju Lu and Yi Zuo},
  journal={Biological psychiatry},
  year={2017},
  volume={82 2},
  pages={
          139-149
        }
}
BACKGROUND Fragile X syndrome (FXS) is the most common type of mental retardation attributable to a single-gene mutation. It is caused by FMR1 gene silencing and the consequent loss of its protein product, fragile X mental retardation protein. Fmr1 global knockout (KO) mice recapitulate many behavioral and synaptic phenotypes associated with FXS. Abundant evidence suggests that astrocytes are important contributors to neurological diseases. This study investigates astrocytic contributions to… CONTINUE READING
6 Citations
51 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…