Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses

Abstract

Neuronal activity alters calcium ion (Ca2+) dynamics in astrocytes, but the physiologic relevance of these changes is controversial. To examine this issue further, we generated an inducible transgenic mouse model in which the expression of an inositol 1,4,5-trisphosphate absorbent, “IP3 sponge”, attenuates astrocytic Ca2+ signaling. Attenuated Ca2+ activity… (More)
DOI: 10.1186/1756-6606-6-6

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@inproceedings{Tanaka2012AstrocyticCS, title={Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses}, author={Mika Tanaka and Pei-Yu Shih and Hiroshi Gomi and Takamasa Yoshida and Junichi Nakai and Reiko Ando and Teiichi Furuichi and Katsuhiko Mikoshiba and Alexey Semyanov and Shigeyoshi Itohara}, booktitle={Molecular Brain}, year={2012} }