Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

@article{Plata2018AstrocyticAF,
  title={Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus},
  author={Alex Plata and Albina V. Lebedeva and Pavel Denisov and Olga Nosova and Tatiana Yu. Postnikova and Alexey S. Pimashkin and Alexey R. Brazhe and Aleksey V. Zaitsev and Dmitri A. Rusakov and Alexey Semyanov},
  journal={Frontiers in Molecular Neuroscience},
  year={2018},
  volume={11}
}
Epilepsy is a group of neurological disorders commonly associated with the neuronal malfunction leading to generation of seizures. Recent reports point to a possible contribution of astrocytes into this pathology. We used the lithium-pilocarpine model of status epilepticus (SE) in rats to monitor changes in astrocytes. Experiments were performed in acute hippocampal slices 2–4 weeks after SE induction. Nissl staining revealed significant neurodegeneration in the pyramidal cell layers of… 
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