Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

  title={Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling},
  author={Randolph Scott Ashton and Anthony Conway and Chinmay Pangarkar and Jamie Bergen and Kwang-Il Lim and Priya S. Shah and Mina J. Bissell and David V. Schaffer},
  booktitle={Nature Neuroscience},
Neurogenesis in the adult hippocampus involves activation of quiescent neural stem cells (NSCs) to yield transiently amplifying NSCs, progenitors, and, ultimately, neurons that affect learning and memory. This process is tightly controlled by microenvironmental cues, although a few endogenous factors are known to regulate neuronal differentiation. Astrocytes have been implicated, but their role in juxtacrine (that is, cell-cell contact dependent) signaling in NSC niches has not been… CONTINUE READING
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