Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats.

@article{SchmidtKastner2005AstrocytesRT,
  title={Astrocytes react to oligemia in the forebrain induced by chronic bilateral common carotid artery occlusion in rats.},
  author={Rainald Schmidt-Kastner and Cristina Aguirre-Chen and Isabel Saul and Linda Yick and Duco I. Hamasaki and Raul Busto and Myron D. Ginsberg},
  journal={Brain research},
  year={2005},
  volume={1052 1},
  pages={28-39}
}
The effects of oligemia (moderate ischemia) on the brain need to be explored because of the potential role of subtle microvascular changes in vascular cognitive impairment and dementia. Chronic bilateral common carotid artery occlusion (BCCAO) in adult rats has been used to study effects of oligemia (hypoperfusion) using neuropathological and neurochemical analysis as well as behavioral tests. In this study, BCCAO was induced for 1 week, or 2, 4, and 6 months. Sensitive immunohistochemistry… CONTINUE READING