Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors.

@article{Kim2011AstrocytesPT,
  title={Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors.},
  author={Sunja Kim and Andrew Jonathan Steelman and Hisami Koito and Jianrong Li},
  journal={Journal of neurochemistry},
  year={2011},
  volume={116 1},
  pages={
          53-66
        }
}
Neuroinflammation and increased production of tumor necrosis factor (TNF) in the CNS have been implicated in many neurological diseases including white matter disorders periventricular leukomalacia and multiple sclerosis. However, the exact role of TNF in these diseases and how it mediates oligodendrocyte injury remain unclear. Previously, we demonstrated that lipopolysaccharide (LPS) selectively kills oligodendrocyte precursors (preOLs) in a non-cell autonomous fashion through the induction of… CONTINUE READING
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Citations

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Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures

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Astrocyte galectin-9 potentiates microglial TNF secretion

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