Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway.

  title={Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway.},
  author={Ulrika Wilhelmsson and Maryam Faiz and Yolanda de Pablo and Marika Sj{\"o}qvist and Daniel Andersson and Asa Widestrand and Maja Potokar and Matja{\vz} Stenovec and Peter L. P. Smith and Noriko Shinjyo and Tulen Pekny and Robert Zorec and Anders St{\aa}hlberg and Marcela Pekna and Cecilia Sahlgren and Milos Pekny},
  journal={Stem cells},
  volume={30 10},
Adult neurogenesis is regulated by a number of cellular players within the neurogenic niche. Astrocytes participate actively in brain development, regulation of the mature central nervous system (CNS), and brain plasticity. They are important regulators of the local environment in adult neurogenic niches through the secretion of diffusible morphogenic factors, such as Wnts. Astrocytes control the neurogenic niche also through membrane-associated factors, however, the identity of these factors… CONTINUE READING
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