Astrocytes in physiological aging and Alzheimer's disease.

  title={Astrocytes in physiological aging and Alzheimer's disease.},
  author={Jos{\'e} J Rodr{\'i}guez-Arellano and Vladimir Parpura and Robert Zorec and Alexei Verkhratsky},
Astrocytes are fundamental for homoeostasis, defence and regeneration of the central nervous system. Loss of astroglial function and astroglial reactivity contributes to the aging of the brain and to neurodegenerative diseases. Changes in astroglia in aging and neurodegeneration are highly heterogeneous and region-specific. In animal models of Alzheimer's disease (AD) astrocytes undergo degeneration and atrophy at the early stages of pathological progression, which possibly may alter the… CONTINUE READING