Astrocytes generate isoprostanes in response to trauma or oxygen radicals.

@article{Hoffman2000AstrocytesGI,
  title={Astrocytes generate isoprostanes in response to trauma or oxygen radicals.},
  author={Seth Hoffman and Beverly A. Rzigalinski and Karen A Willoughby and Earl F. Ellis},
  journal={Journal of neurotrauma},
  year={2000},
  volume={17 5},
  pages={415-20}
}
Previous studies have shown that oxygen radical scavengers prevent the reduced cerebral blood flow that occurs following experimental traumatic brain injury. The exact chemical species responsible for the posttraumatic reduction in flow is unknown. We tested whether isoprostanes, which are formed by non-cyclooxygenase-dependent free radical attack of arachidonic acid and are vasoconstrictors of the cerebral circulation, are increased in astrocytes following stretch-induced trauma or injury with… CONTINUE READING

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