Astrocytes facilitate melanoma brain metastasis via secretion of IL-23.

  title={Astrocytes facilitate melanoma brain metastasis via secretion of IL-23.},
  author={Anat Klein and Hila Schwartz and Orit Sagi-Assif and Tsipi Meshel and Sivan Izraely and Shlomit Ben Menachem and Roman Bengaiev and Amir Ben-Shmuel and Clara Nahmias and P Olivier Couraud and Isaac P Witz and Neta Erez},
  journal={The Journal of pathology},
  volume={236 1},
Melanoma is the leading cause of skin cancer mortality. The major cause of melanoma mortality is metastasis to distant organs, frequently to the brain. The microenvironment plays a critical role in tumourigenesis and metastasis. In order to treat or prevent metastasis, the interactions of disseminated tumour cells with the microenvironment at the metastatic organ have to be elucidated. However, the role of brain stromal cells in facilitating metastatic growth is poorly understood. Astrocytes… CONTINUE READING


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