Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

@article{Papadeas2011AstrocytesCT,
  title={Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.},
  author={Sophia T Papadeas and Sarah E Kraig and Colin P O'Banion and Angelo C. Lepore and Nicholas J. Maragakis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 43},
  pages={17803-8}
}
Recent studies highlight astrocytes as key drivers of motor neuron (MN) degeneration and disease propagation in mutant human superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis. However, in vivo analysis of specific astrocytic influence in amyotrophic lateral sclerosis has proven difficult because mSOD1 is ubiquitously expressed throughout the CNS of rodent models studied. Here, we transplanted SOD1(G93A) glial-restricted precursor cells--glial progenitors capable of… CONTINUE READING

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