Astrocytes as gatekeepers of GABAB receptor function.

  title={Astrocytes as gatekeepers of GABAB receptor function.},
  author={Mark P. Beenhakker and John R. Huguenard},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 45},
The long-lasting actions of the inhibitory neurotransmitter GABA result from the activation of metabotropic GABA(B) receptors. Enhanced GABA(B)-mediated IPSCs are critical for the generation of generalized thalamocortical seizures. Here, we demonstrate that GABA(B)-mediated IPSCs recorded in the thalamus are primarily defined by GABA diffusion and activation of distal extrasynaptic receptors potentially up to tens of micrometers from synapses. We also show that this diffusion is differentially… CONTINUE READING

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