Astrocytes are target cells for endothelins and sarafotoxin.

  title={Astrocytes are target cells for endothelins and sarafotoxin.},
  author={Robert Marsault and Paul Vigne and J P Breittmayer and Christian Frelin},
  journal={Journal of neurochemistry},
  volume={54 6},
Endothelin-1, endothelin-3, and the snake venom toxin sarafotoxin S6b stimulate the hydrolysis of phosphatidylinositol by phospholipase C with similar potencies in primary cultures of astrocytes prepared from rat brain cortex. In indo 1-loaded cells, endothelin-1, endothelin-2, endothelin-3, and sarafotoxin induce the rapid mobilization of intracellular Ca2+ stores and promote a more slowly developing influx of Ca2+. These responses were insensitive to pertussis toxin and to inhibitors of… CONTINUE READING