Astrocytes are involved in long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain.

@article{Ikeda2013AstrocytesAI,
  title={Astrocytes are involved in long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain.},
  author={Hiroshi Ikeda and Keiichi Mochizuki and Kazuyuki Murase},
  journal={Pain},
  year={2013},
  volume={154 12},
  pages={2836-43}
}
Neuronal plasticity in the pain-processing pathway is thought to be a mechanism underlying pain hypersensitivity and negative emotions occurring during a pain state. Recent evidence suggests that the activation of astrocytes in the anterior cingulate cortex (ACC) contributes to the development of negative emotions during pain hypersensitivity after peripheral inflammation. However, it is unknown whether these activated astrocytes contribute to neuronal plasticity in the ACC. In this study, by… CONTINUE READING