Astrocytes and Synaptosomes Transport and Metabolize Lactate and Acetate Differently

@article{Waniewski2004AstrocytesAS,
  title={Astrocytes and Synaptosomes Transport and Metabolize Lactate and Acetate Differently},
  author={Robert A. Waniewski and David L. Martin},
  journal={Neurochemical Research},
  year={2004},
  volume={29},
  pages={209-217}
}

• Robert A. Waniewski, David L. Martin
• Published 2004 in Neurochemical Research
• DOI:10.1023/B:NERE.0000010450.21586.a6

Astrocytes transport the monocarboxylate acetate, but synaptosomes do not. The reason for this is unknown, because both preparations express monocarboxylate transporters (MCT). The transport and metabolism of lactate, another monocarboxylate, was examined in these two preparations, and the results were compared to those for acetate. Lactate transport is more rapid in astrocytes than in synaptosomes, but of lower affinity (Kms of 17 and 4 mM, respectively). Lactate (0.2 mM) is metabolized to CO2… CONTINUE READING

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