Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS

@inproceedings{Lee2016AstrocytesAM,
  title={Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS},
  author={Junghee Lee and Seung Jae Hyeon and Hyeonjoo Im and Hyun Mee Ryu and Yunha Kim and Hoon Ryu},
  booktitle={Experimental neurobiology},
  year={2016}
}
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that leads to a progressive muscle wasting and paralysis. The pathological phenotypes are featured by severe motor neuron death and glial activation in the lumbar spinal cord. Proposed ALS pathogenic mechanisms include glutamate cytotoxicity, inflammatory pathway, oxidative stress, and protein aggregation. However, the exact mechanisms of ALS pathogenesis are not fully understood yet. Recently, a growing body of… CONTINUE READING

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