Astrocytes Play a Key Role in Drosophila Mushroom Body Axon Pruning

  title={Astrocytes Play a Key Role in Drosophila Mushroom Body Axon Pruning},
  author={Yaniv Hakim and Shiri Penina Yaniv and Oren Schuldiner},
  booktitle={PloS one},
Axon pruning is an evolutionarily conserved strategy used to remodel neuronal connections during development. The Drosophila mushroom body (MB) undergoes neuronal remodeling in a highly stereotypical and tightly regulated manner, however many open questions remain. Although it has been previously shown that glia instruct pruning by secreting a TGF-β ligand, myoglianin, which primes MB neurons for fragmentation and also later engulf the axonal debris once fragmentation has been completed, which… CONTINUE READING
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