Astrocytes Play a Key Role in Drosophila Mushroom Body Axon Pruning

@inproceedings{Hakim2014AstrocytesPA,
  title={Astrocytes Play a Key Role in Drosophila Mushroom Body Axon Pruning},
  author={Yaniv Hakim and Shiri Penina Yaniv and Oren Schuldiner},
  booktitle={PloS one},
  year={2014}
}
Axon pruning is an evolutionarily conserved strategy used to remodel neuronal connections during development. The Drosophila mushroom body (MB) undergoes neuronal remodeling in a highly stereotypical and tightly regulated manner, however many open questions remain. Although it has been previously shown that glia instruct pruning by secreting a TGF-β ligand, myoglianin, which primes MB neurons for fragmentation and also later engulf the axonal debris once fragmentation has been completed, which… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 31 references

Ensheathing glia function as phagocytes in the adult Drosophila brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2009
View 6 Excerpts
Highly Influenced

Alteration of astrocytes and Wnt/beta-catenin signaling in the frontal cortex of autistic subjects

F Cao, A Yin, G Wen, AM Sheikh, Z Tauqeer
J Neuroinflammation • 2012
View 1 Excerpt

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