Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat.

@article{Robinson2014AstrocytesBN,
  title={Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat.},
  author={Caleb R Robinson and Haiming Zhang and Patrick M Dougherty},
  journal={Neuroscience},
  year={2014},
  volume={274},
  pages={308-17}
}
Spinal microglia are widely recognized as activated by and contributing to the generation and maintenance of inflammatory and nerve injury related chronic pain; whereas the role of spinal astrocytes has received much less attention, despite being the first glial cells identified as activated following peripheral nerve injury. Recently it was suggested that microglia do not appear to play a significant role in chemotherapy-induced peripheral neuropathy (CIPN), but in contrast astrocytes appear… CONTINUE READING
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