Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury.

  title={Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury.},
  author={Milena Penkowa and Mercedes Giralt and Natalia Lago and Jordi Camats and Javier Carrasco and Joaqu{\'i}n Hern{\'a}ndez and Amalia Molinero and Iain L Campbell and Juan Hidalgo},
  journal={Experimental neurology},
  volume={181 2},
The effect of CNS-targeted IL-6 gene expression has been thoroughly investigated in the otherwise nonperturbed brain but not following brain injury. Here we examined the impact of astrocyte-targeted IL-6 production in a traumatic brain injury (cryolesion) model using GFAP-IL6 transgenic mice. This study demonstrated that transgenic IL-6 production significantly increased wound healing following the cryolesion. Thus, at 20 days postlesion (dpl) the GFAP-IL6 mice showed almost complete wound… CONTINUE READING
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