Astrocyte scar formation aids central nervous system axon regeneration

  title={Astrocyte scar formation aids central nervous system axon regeneration},
  author={M Bronwell Anderson and Joshua E. Burda and Yilong Ren and Yan Ao and Timothy M. O’Shea and Riki Kawaguchi and Giovanni Coppola and Baljit S. Khakh and Timothy J Deming and Michael V Sofroniew},
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte scar formation, attenuating scar-forming astrocytes, or ablating chronic astrocytic scars all failed to result in spontaneous regrowth of transected corticospinal, sensory or serotonergic axons through severe spinal cord injury (SCI) lesions. By… CONTINUE READING
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