Astrocyte-mediated ischemic tolerance.

  title={Astrocyte-mediated ischemic tolerance.},
  author={Yuri Hirayama and Yuri Ikeda-Matsuo and Shoji Notomi and Hiroshi Enaida and Hiroyuki Kinouchi and Schuichi Koizumi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={35 9},
Preconditioning (PC) using a preceding sublethal ischemic insult is an attractive strategy for protecting neurons by inducing ischemic tolerance in the brain. Although the underlying molecular mechanisms have been extensively studied, almost all studies have focused on neurons. Here, using a middle cerebral artery occlusion model in mice, we show that astrocytes play an essential role in the induction of brain ischemic tolerance. PC caused activation of glial cells without producing any… CONTINUE READING
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