Astrocyte loss and astrogliosis in neuroinflammatory disorders.

  title={Astrocyte loss and astrogliosis in neuroinflammatory disorders.},
  author={St{\'e}phanie Hostenbach and Melissa Cambron and Miguel D'haeseleer and R. Kooijman and Jacques De Keyser},
  journal={Neuroscience letters},
Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-α in major depressive disorder. Interleukins-1 and -6 appear to be important molecular mediators of astrogliosis. Chronic focal lesions in multiple sclerosis are characterized by a very dense astrogliosis. Other mechanisms, such as… CONTINUE READING