Astrocyte intermediate filaments in CNS pathologies and regeneration.

  title={Astrocyte intermediate filaments in CNS pathologies and regeneration.},
  author={Milos Pekny and Marcela Pekna},
  journal={The Journal of pathology},
  volume={204 4},
Astroglial cells are the most abundant cells in the mammalian central nervous system (CNS), yet our knowledge about their function in health and disease has been limited. This review focuses on the recent work addressing the function of intermediate filaments in astroglial cells under severe mechanical or osmotic stress, in hypoxia, and in brain and spinal cord injury. Recent data show that when astrocyte intermediate filaments are genetically ablated in mice, reactive gliosis is attenuated and… CONTINUE READING
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