Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury.

@article{Macaya2013AstrocyteII,
  title={Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury.},
  author={Daniel J. Macaya and Kazuhide Hayakawa and Ken Arai and Myron Spector},
  journal={Biomaterials},
  year={2013},
  volume={34 14},
  pages={3591-602}
}
Astrocytes can play dual roles in the response to spinal cord injury (SCI) acting as both an inhibitory barrier and a trophic support for growth axons. Therefore, migration of these cells into the defect as opposed to forming a scar at the periphery, may promote axon regeneration through the lesion. However, infiltration requires the conformal filling of the cyst-like lesion, which often forms after SCI, with a biomaterial scaffold encouraging of astrocyte migration. For this application, we… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 58 references

Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 2 Excerpts

Injectable collagen-genipin gel for the treatment of spinal cord injury: in vitro studies

D Macaya, KK Ng, M. Spector
Adv Funct Mater • 2011
View 2 Excerpts

Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 2 Excerpts

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