Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.

@article{Xiao2002AstrocyteIO,
  title={Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.},
  author={Andrew Xiao and Hua Wu and Pier Paolo Pandolfi and David N Louis and Terry A. van Dyke},
  journal={Cancer cell},
  year={2002},
  volume={1 2},
  pages={157-68}
}
We have inactivated pRb, p107, and p130 in astrocytes by transgenic expression of T(121) (a truncated SV40 T antigen) under the GFAP promoter. Founder mice died perinatally with extensive expansion of neural precursor and anaplastic astrocyte populations. In astrocytes, aberrant proliferation and extensive apoptosis were induced. Using a conditional allele of T(121), early lethality was circumvented, and adult mice developed high-grade astrocytoma, in which regions of decreased apoptosis… CONTINUE READING

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